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Vincent Colot

Arabidopsis Epigenetics and Epigenomics

Goal
To unravel chromatin-based epigenetic processes and their contribution to heritable phenotypic variation in plants using (epi)genomic and genetic approaches.

Background


Chromatin is the natural substrate on which DNA transactions take place within the nucleus of eukaryotic cells. Chromatin is a highly dynamic structure and how distinct chromatin states are established, maintained and erased to modulate the function of the genome as well as the creation of new DNA sequence variation are fundamental questions in biology.

Research highlights


Our group investigates the contribution of chromatin-based epigenetic processes to heritable phenotypic variation, using the reference flowering plant Arabidopsis as well as tomato. Specifically, we are studying the dynamics of DNA methylation during plant life and the inheritance patterns of DNA methylation variants, with the goal of understanding how epimutations arise, what conditions their stability across generations and what is their phenotypic impact.
Given that transposable elements (TEs) and other repeat sequences are the primary targets of DNA methylation in plants and are involved in the creation of epimutable alleles of genes, we have also a strong interest in the study of TE mobilization and its control.