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Publications of the team

Beets, I., Zhang, G., Fenk, L., Chen, C., Nelson, G.M., Félix, M.-A.# and de Bono, M.# (2020). Natural variation in a dendritic scaffold protein modifies experience-dependent plasticity by altering neuropeptide expression. Neuron 15, 1-16. Link

Richaud, A., Frézal, L., Tahan, S., Zhao, G., Kaur, T., Wang, D.# and Félix, M.-A.# (2019). Vertical transmission in Caenorhabditis nematodes of RNA molecules encoding a viral RNA-dependent RNA polymerase. Proc. Natl. Acad. Sci USA, online. Link

Lee, D., Zdraljevic, S., Cook, D.E., Frézal, L., Hsu, J.-C., Sterken, M.G., Riksen, J.A.G., Wang, J., Kammenga, J.E., Braendle, C., Félix, M.-A., Schroeder, F.C. and Andersen, E.C. (2019). Selection and gene flow shape niche-associated variation in pheromone response. Nature Ecology and Evolution 3, 1455-1463. Link

Frézal, L., Jung, H., Tahan, S. Wang, D. and Félix, M.-A. (2019). Noda-like RNA viruses infecting Caenorhabditis nematodes : sympatry, diversity and reassortment. J. Virol. 93, e01170-19. Link

Félix, M.-A.# and Wang, D. Natural viruses of Caenorhabditis. (2019). Annu Rev. Genet. 53, in press. Link

Grosmaire, M.*, Launay, C.*, Siegwald, M., Brugière, T., Estrada-Virrueta, L., Berger, D., Burny, C., Modolo, L., Blaxter, M., Meister, P., Félix, M.-A., Gouyon, P.-H., Delattre, M. (2019). Males as somatic investment in a parthenogenetic nematode. Science 363, 1210-1213. Link

Stevens, L., Félix, M.-A., Beltran, T., Braendle, C., Caurcel, C., Fausett, C., Fitch, D.H.A., Frézal, L., Kaur, T., Kiontke, K.C., Newton, M.D., Noble, L.M., Richaud, A., Rockman, M.V., Sudhaus, W. Blaxter, M. (2019). Comparative genomics of ten new Caenorhabditis species. Evolution Letters 3-2, 217–236. Link

Page, A.P., Roberts, M., Félix, M.-A., Pickard, D., Page, A., Weir, W. (2019). The golden death bacillus Chryseobacterium nematophagum is a novel matrix digesting pathogen of nematodes. BMC Biol 17, 10. Link

Vargas-Velazquez, A.M., Besnard, F. and Félix, M.-A. (2019). Necessity and contingency in developmental genetic screens : LIN-3, Wnt and semaphorin pathways in vulval induction of the nematode Oscheius tipulae. Genetics 211, 1315-1330. Link

Grimbert, S., Vargas Velazquez, A.M., Braendle, C. (2018). Physiological starvation promotes Caenorhabditis elegans vulval induction. G3 8, 3069. Link

Félix, M.-A., Ailion, M., Hsu, J.-C., Richaud, A. and Wang, J. (2018). Pristionchus nematodes occur frequently in diverse rotting vegetal substrates and are not exclusively necromenic, while Panagrellus redivivoides is found specifically in rotting fruits. PLOS One 13,e0200851. Link

Frézal, L., Demoinet, E., Braendle, C., Miska, E# and Félix, M.-A.# (2018). Natural genetic variation in a multigenerational phenotype in C. elegans. Current Biology 28, 2588-2596. Link

Osman, G.A.*, Fasseas, M.K.*, Koneru, S.L., Essmann, C.L., Kyrou, K., Srinivasan, M.A., Zhang, G., Sarkies, P., Félix, M.-A and Barkoulas, M. (2018). Natural infection of C. elegans by an oomycete reveals a new pathogen-specific immune response. Current Biology 28, 640-648. Link

Richaud, A., Zhang, G., Lee, D. Lee, J. and Félix, M-A. (2018). The local co-existence pattern of selfing genotypes in Caenorhabditis elegans natural metapopulations. Genetics 208, 807-821. Link

Besnard, F.*, Koutsovoulos, G.*, Dieudonné, S., Blaxter, M.# and Félix, M.-A.# (2017). Towards universal forward genetics : using a draft genome sequence of the nematode Oscheius tipulae to identify mutations affecting vulva development. Genetics 206, 1747-1761. Link

Schulenburg, H., and Félix, M.-A. (2017). The natural biotic environment of C. elegans. Genetics 206, 55-86. Link

Zhang, F.*, Berg, M.*, Dierking, K., Félix, M.-A., Shapira, M.#, Samuel, B.# and Schulenburg, H.# (2017). Caenorhabditis elegans as a model for microbiome research. Frontiers in Microbiology 8, 485. Link

Nigon, V.M. and Félix, M.-A. (2017) History of research on C. elegans and other free-living nematodes as model organisms. Wormbook, The C. elegans research Community, ed. doi/10.1895/wormbook.1.181.1. Link

Zhang, G., Sachse, M., Prevost, M.-C., Luallen, R.J., Troemel, E. and Félix, M.-A. (2016). A large collection of novel nematode-infecting microsporidia and their diverse interactions with Caenorhabditis elegans and other related nematodes. PLOS Pathogens 12, e1006093. Link

Barkoulas, M.*#, Vargas Velazquez, A.M*, Peluffo, A.E. and Félix, M.-A.# (2016). Evolution of new cis-regulatory motifs required for cell-specific gene expression in Caenorhabditis. PLOS Genetics 12, e1006278. Link

Cook, D.C., Zdraljevic, S., Tanny, R.E., Seo, B., Riccardi, D.D., Noble, L.M., Rockman, M.V., Alkema, M.J., Braendle, C., Kammenga, J.E., Wang, J., Kruglyak, L., Félix, M-A., Lee, J., Andersen, E.C. (2016). The genetic basis of natural variation in C. elegans telomere length. Genetics 204, 371-383. Link

Grimbert, S., Tietze, K., Barkoulas, M., Sternberg, P.W., Félix, M.-A. and Braendle, C. (2016). Anchor cell signaling anf vulval precursor cell positioning establish a reproducible spatial context during C. elegans vulval induction. Dev. Biol. 416, 123-135. Link

Luallen, R.J., Reinke, A.W., Tong, L., Botts, M.R., Félix, M.-A. and Troemel, E.R. (2016). Discovery of a natural microsporidian pathogen with a broad tissue tropism in Caenorhabditis elegans. PLOS Pathogens 12, e1005724. Link

Samuel, B.S., Rowedder, H., Braendle, C., Félix, M.-A.* and Ruvkun, G.* (2016). Caenorhabditis elegans responses to bacteria from its natural habitats. Proc. Natl. Acad. Sci. USA 113, E3941-3949. Link

Dirksen, P., Arnaud Marsh, S., Braker, I., Heitland, N., Wagner, S., Nakad, R., Mader, S., Petersen, C., Kowallik, V., Rosenstiel, P., Félix, M-A. and Schulenburg, H. (2016). The native microbiome of the nematode Caenorhabditis elegans : Gateway to a new host-microbiome model. BMC Biol. 14:38. Link

Félix, M.-A. Phenotypic evolution with and beyond genome evolution. Curr. Top. Dev. Biol. 119, 291-347. Link

Félix, M.-A. and Barkoulas, M. (2015). Pervasive robustness in biological systems. Nat. Rev. Genet. 16, 483-496. Link

Frézal, L. and Félix, M.-A. (2015). C. elegans outside the Petri dish. eLife 4:e05849. Link

McGill, L.M., Shannon, A.J., Pisani, D., Félix, M.-A., Ramløv, H., Dix, I., Wharton, D.A. and Burnell, A.M. (2015). Anhydrobiosis and freezing-tolerance : adaptations that facilitate the establishment of Panagrolaimus nematodes in polar habitats. PLoS One 10:e0116084. Link

Barrière, A. and Félix, M.-A. (2014). Isolation of C. elegans and related nematodes. Wormbook, The C. elegans Research Community, ed. doi/10.1895/wormbook.1.115.2 Link

Félix, M.-A., Braendle, C., Cutter, A.D. (2014). A streamlined system for species diagnosis in Caenorhabditis (Nematoda : Rhabditidae) with name designations for 15 distinct biological species. PLoS One 9:e94723. Link

Franz, C., Renshaw, H., Frézal, L., Jiang, Y., Félix, M.-A., Wang, D. (2014). Orsay, Santeuil and Le Blanc viruses primarily infect intestinal cells in Caenorhabditis nematodes. Virology 448, 255-264. Link

Hodgkin, J., Félix, M.-A., Clark, L.C., Stroud, D., Gravato-Nobre, M.J. (2013). Two Leucobacter strains exert complementary virulence on Caenorhabditis including death by worm-star formation. Curr. Biol. 23, 2157-2161. Link

Ashe, A.*, Bélicard, T.*, Le Pen, J.*, Sarkies, P.*, Frézal, L., Lehrbach, N.J., Félix, M.-A.# and Miska, E.A.# (2013). A deletion polymorphism in the C. elegans RIG-I homolog disables viral RNA dicing and antiviral immunity. eLife 2:e00994. Link

Félix, M.-A.*, Jovelin, R.*, Ferrari, C., Han, S., Cho, Y.R., Andersen, E.C., Cutter, A.D., Braendle, C. (2013). Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest. BMC Evol. Biol. 13, 10. Link

Barkoulas, M., van Zon, J.S., Milloz, J., van Oudenaarden, A., Félix, M.-A. (2013). Robustness and epistasis in the C. elegans vulval signalling network revealed by pathway dosage modulation. Dev. Cell 24, 64-75. Link

Félix, M.-A. (2012). Evolution in developmental phenotype space. Curr. Op. Gen. Dev. 22, 593–599. Link

Franz, C., Zhao, G., Félix, M.-A., Wang, D. (2012). Complete genome sequence of Le Blanc virus, a third Caenorhabditis nematode infecting virus. J. Virology 86, 11940. Link

Félix, M.-A. (2012). Caenorhabditis elegans vulval cell fate patterning. Phys. Biol. 9, 045001. Link

Bélicard, T. and Félix, M.-A. (2012). Transmission multigénérationnelle de l’interférence à l’ARN chez le nématode C. elegans. Médecine/sciences 28, 574-577.

Félix, M.-A. and Duveau, F. (2012). Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae. BMC Biology 10, 59. Link

Félix, M.-A. and Barkoulas, M. (2012). Robustness and flexibility in nematode vulva development. Trends in Genetics 28, 185-195. Link

Gerke, J.P.*, Andersen, A.C.*, Shapiro J.A.*, Crissman, J.R., Ghosh, R., Bloom, J.S., Félix, M.-A. and Kruglyak, L. (2012). Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nature Genetics 44, 285-290. Link

Nuez, I. and Félix M.-A. (2012). Evolution of susceptibility to ingested double-stranded RNAs in Caenorhabditis nematodes. PLoS One 7, e29811. Link

Duveau, F. and Félix, M.-A. (2012). Role of pleiotropy in the evolution of a cryptic developmental variation in C. elegans. PLoS Biol. 10, e1001230. Link

Kiontke, K.*, Félix, M.-A.*, Ailion, M., Rockman, M.V., Braendle, C., Pénigault, J.-B. and Fitch, D.H.A. (2011). A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits. BMC Evol. Biol. 11, 339. Link

Pénigault, J.-B. and Félix, M.-A. (2011). Evolution of a system sensitive to stochastic noise : P3.p cell fate in Caenorhabditis. Dev. Biol. 357, 419-427. Link

Pénigault, J.-B. and Félix, M.-A. (2011). High sensitivity of C. elegans vulval precursor cells to the dose of posterior Wnts. Dev. Biol. 357, 428-438. Link

Hoyos, E.*, Kim, K.*, Milloz, J., Barkoulas, M., Pénigault, J.-B., Munro, E. and Félix, M.-A. (2011). Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabdidtis vulva network. Curr. Biol. 21, 527-538. Link

Félix, M.-A.*#, Ashe, A.*, Piffaretti, P.*, Wu, G., Nuez, I., Bélicard, T. , Jiang, Y., Zhao, G., Franz, C.J., Goldstein, L.D., Sanroman, M., Miska, E.A.# and Wang, D.# (2011). Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. PLoS Biol. 9, e1000586. Link

Félix, M.-A. and Braendle, C. (2010). The natural history of Caenorhabditis elegans. Curr. Biol. 20, R965-969 (Primer). Link

Woodruff, G.C., Eke, O., Baird, S.E., Félix, M.-A. and Haag, E.S. (2010). Insights into species divergence and the evolution of hermaphroditism from fertile interspecies hybrids of Caenorhabditis nematodes. Genetics 186, 997-1012. Link

Duveau, F. and Félix, M.-A. (2010). Hidden variation mapped. Heredity 105, 423-425. Link

Braendle, C., Baer, C. and Félix, M.-A. (2010). Evolution of the mutationally accessible phenotypic space in a developmental system. PLoS Genetics 6, e1000877. Link

Cutter, A.D., Yan, W., Tsvetkov, N., Sunil, S. and Félix, M.-A. (2010). Molecular population genetics and phenotypic sensitivity to ethanol for a globally diverse sample of the nematode Caenorhabditis briggsae. Mol. Ecol. 19, 798-809. Link

Raboin, M.J., Timko, A.F., Howe, D.K., Félix, M.-A., and Denver, D.R. (2010). Evolution of Caenorhabditis mitochondrial genome pseudogenes and C. briggsae natural isolates. Mol. Biol. Evol. 27, 1087-1096. Link

Félix, M.-A. (2009). Variations génétiques et environnementales dans un réseau de signalisation intercellulaire. Médecine/sciences 25, 705-712. Link

Braendle, C. and Félix, M.-A. (2009). New fashion models. Nat. Cell Biol. 11, 668. Link

Delattre, M. and Félix, M.A. (2009). The evolutionary context of robust and redundant cell biological mechanisms. Bioessays 31, 537-545. Link

Braendle, C. and Félix, M.-A. (2009). The other side of phenotypic plasticity : a developmental system that generates an invariant phenotype despite environmental variation. J. Biosciences 34, 543-551. Link

Troemel, E.R., Félix, M.-A., Whiteman, N.K., Barrière, A. and Ausubel, F.M. (2008). Microsporidia are natural intracellular parasites of the nematode C. elegans. PLoS Biol. 6, e309. Link

Félix, M.-A. (2008). RNA interference in nematodes and the chance that favored Sydney Brenner. J. Biol. 7, 34. Link

Braendle, C. and Félix, M.-A. (2008). Plasticity and errors of a robust developmental system in different environments. Dev. Cell 15, 714-724. Link

Milloz, J., Duveau, F., Nuez, I. and Félix, M.-A. (2008). Intraspecific evolution of the intercellular signaling network underlying a robust developmental system. Genes Dev. 22, 3064-3075. Link

Félix, M.-A. (2008). Q&A : Marie-Anne Félix. Curr. Biol. 18, R636-637. Link

Baïlle, D., Barrière, A. and Félix, M.-A. (2008). Oscheius tipulae, a widespread hermaphroditic soil nematode, displays a higher genetic diversity and geographic structure than Caenorhabditis elegans. Mol. Ecol. 17, 1523-1534. Link

Dolgin, E.S. Félix, M.-A. and Cutter, A.D. (2008). Hakuna Nematoda : Genetic and phenotypic diversity in African isolates of Caenorhabditis elegans and C. briggsae. Heredity 100, 304-315. Link

Braendle, C., Milloz, J. and Félix, M.-A. (2008). Mechanisms and evolution of environmental responses in Caenorhabditis elegans. Curr. Top. Dev. Biol. 80, 171-207. Link

Félix, M.-A. and Wagner, A. (2008). Robustness and evolution : concepts, insights, and challenges from a developmental model system. Heredity 100, 132-140. Link

Kiontke, K., Barrière, A., Kolotuev, I., Podbilewicz, B., Sommer, R., Fitch, D.H.A. and Félix, M.-A. (2007). Evolution of development in the nematode vulva system : trends, stasis and drift. Curr. Biol. 17, 1925-1937. Link

Winter, A.D., Keskiaho, K., Kukkola, L., McCormack, G., Félix, M.-A., Myllyharju, J. and Page, A.P. (2007). Differences in collagen prolyl 4-hydroxylase assembly between two Caenorhabditis nematode species despite high amino acid sequence identity of the enzyme subunits. Matrix Biology 26, 382-395. Link

Barrière, A. and Félix, M.-A. (2007). Temporal dynamics and linkage disequilibrium in natural C. elegans populations. Genetics 176, 999-1011. Link

Félix, M.-A. (2007). Cryptic quantitative evolution of the vulva intercellular network in Caenorhabditis. Curr. Biol. 17, 103-114.Link

Félix, M.-A. (2006). Oscheius tipulae. Wormbook, The C. elegans research Community, ed. doi/10.1895/wormbook.1.119.1 Link

Cutter, A.D., Félix, M.-A., Barrière, A. and Charlesworth, D. (2006). Patterns of nucleotide polymorphism distinguish temperate and tropical wild isolates of Caenorhabditis briggsae. Genetics 173, 2033-2038. Link

Braendle, C. and Félix, M.-A. (2006). Sex determination : Ways to evolve a hermaphodite. Curr. Biol. 16, R468-R471. Link

Flatt, T. and Braendle, V. (2006). A role for genetic accommodation in evolution ? Bioessays 28, 868-873. Link

Barrière, A. and Félix, M.-A. (2006). Isolation of C. elegans and related nematodes. Wormbook, The C. elegans research Community, ed. doi/10.1895/wormbook.1.115.1 Link

Barrière, A. and Félix, M.-A. (2005). Natural variation and population genetics of Caenorhabditis elegans. Wormbook, The C. elegans research Community, ed. doi/10.1895/wormbook.1.43.1Link

Barrière, A. and Félix, M.-A. (2005). High local genetic diversity and low outcrossing rate in Caenorhabditis elegans natural populations. Curr. Biol. 15, 1176-1184. Link

Maupas, E. (1900), English translation by Félix, M.-A. (2005). Modes and forms of reproduction of nematodes. Wormbase. Link

( Félix, M.-A. (2005). An inversion in the wiring of an intercellular signal : evolution of Wnt signaling in the nematode vulva. Bioessays 27, 765-769.) see Note Link

Félix, M.-A. and Barrière, A. (2005). Evolvability of cell specification mechanisms. J. Exp. Zool. (Mol. Dev. Evol.) 304B, 536-547. Link

Dichtel-Danjoy, M.-L. and Félix, M.-A. (2004). Phenotypic neighborhood and micro-evolvability. TIG 20, 268-276. Link

Félix, M.-A. (2004). Alternative morphs and plasticity of vulval development in a rhabditid nematode species. Dev. Genes Evol. 214, 55-63. Link

Félix, M.-A. (2003). Développement et systématique chez les nématodes (Ordre Rhabditida). Biosystema 21.

Félix, M.-A. (2004). Genomes : a helpful cousin for our favourite worm. Curr. Biol. 14, R75-R77. Link

Dichtel-Danjoy, M.-L. and Félix, M.-A. (2004). The two steps of vulval induction in Oscheius tipulae CEW1 recruit common regulators including a MEK kinase. Dev. Biol. 265, 113-126. Link

Félix, M.-A. (2004). Developmental biology of nematodes - what we learn from Caenorhabditis elegans. In Nematology advances and perspectives : nematode management and utilization. Z.X. Chen, S.Y. Chen, D.W. Dickson, Eds. CABI Publishing, vol. I, pp. 71-174.

Bonnaud, L., Delattre, M. and Félix, M.-A. (2004). Division and fate of vulval precursor cells : is polymorphism an image of interspecific divergence ? Nematology Monographs & Perspectives, vol. 2, 691-694.

Louvet-Vallée, S., Kolotuev, I., Podbilewicz, B. and Félix, M.-A. (2003). Control of vulval competence and centering in the nematode Oscheius sp. 1 CEW1. Genetics 163, 133-146. Link

Félix, M.-A., Labouesse, M. and Ségalat, L. (2002) Caenorhabditis elegans, un organisme modèle pour la biologie. Editions Hermann, Paris. 200 pp.

Delattre, M. and Félix, M.-A. (2001). Microevolutionary studies in nematodes : a beginning. Bioessays 23, 807-819. Link

Félix, M.-A., Vierstraete, A. and Vanfleteren, J. (2001). Three biological species related to Rhabditis (Oscheius) pseudodolichura Körner in Osche, 1952. J. Nematol. 33, 104-109. Link

Delattre, M. and Félix, M.-A. (2001). Polymorphism and evolution of vulval precursor cell lineages within two nematode genera, Caenorhabditis and Oscheius. Curr. Biol. 11, 631-643. Link

Delattre, M. and Félix, M.-A. (2001). Evolution and development of a variable left-right asymmetry in nematodes : the handedness of P11/P12 migration. Dev. Biol. 232, 362-371. Link

Dichtel, M.-L.*, Louvet-Vallée, S.*, Viney, M.E.*, Félix, M.-A., Sternberg, P.W. (2001). Control of vulval cell division number in the nematode Oscheius/Dolichorhabditis sp. CEW1. Genetics 157, 183-197. Link

Félix, M.-A., De Ley, P., Sommer, R.J., Frisse, L., Nadler, S.A., Thomas, W.K., Vanfleteren, J. and Sternberg, P.W. (2000). Evolution of vulva development in the Cephalobina (Nematoda). Dev. Biol. 221, 68-86. Link

Félix, M.-A., Delattre, M. and Dichtel, M.-L. (2000). Comparative developmental studies using Oscheius / Dolichorhabditis sp. CEW1 (Rhabditidae). Nematology 2, 89-98.Link

Delattre, M. and Félix, M.-A. (1999). Connection of vulval and uterine epithelia in Caenorhabditis elegans. Biol. Cell 91, 573-583. Link

Louvet-Vallée, S. and Félix, M.-A. (1999). Le lien entre reproduction et longévité... chez C. elegans. Médecine/sciences 15, 1293-1294. Link

De Ley, P., Félix, M.-A., Frisse, L. M., Nadler, S. A., Sternberg, P. W. and Thomas, W. K. (1999). Molecular and morphological characterisation of two reproductively isolated species with mirror-image anatomy (Nematoda : Cephalobidae). Nematology 1, 591-612. Link

Félix, M.-A. (1999). Evolution of developmental mechanisms in nematodes. J. Exp. Zool. (Mol. Dev. Evol.) 285, 3-18. Link