Accèder directement au contenu

Leila Tirichine

Leila Tirichin

Email : tirichin chez

Research interests
. Genome and epigenome mediated regulation of diatom life cycle and responses to environmental cues (genetic diversity, monoallelism, DNA methylation, Adenine methylation, Post translational modifications of histones, non coding RNA)
. Ecology and evolution of diatoms and species plasticity
. Diatom bacteria interactions

Education and qualifications
2000 PhD in Molecular and Cellular Biology. Laboratoire des interactions Plantes Micro-organismes (Institut National Polytechnique Toulouse, INRA CNRS – Castanet, France).
1996 Master, Genetics and Plant Breeding (Ecole Nationale Supérieure d’Agronomie, Rennes, France).
1995 Plant Biotechnologies Engineer diploma (Ecole Nationale Supérieure d’Agronomie, Toulouse, France).
2017- CNRS Research Director - Ecole Normale Supérieure, Paris
2009-2017 CNRS research scientist - Ecole Normale Supérieure, Paris
2009 Post Doc at Institut des Sciences du Végétal, CNRS, Gif sur Yvette, France
2006-2008 Post Doc at INRA, Laboratory of Cellular Biology, Versailles, France
2001-2006 Assistant Professor at Aarhus University, Laboratory of Gene Expression, Department of Molecular Biology, Aarhus C (Denmark)


- Leila Tirichine, Achal Rastogi and Chris Bowler* Recent progress in diatom genomics and epigenomics. Current Opinions in Plant Biology (2017)

- Rastogi A, Murik O, Bowler C, Tirichine L. PhytoCRISP-Ex : a web-based and stand-alone application to find specific target sequences for CRISPR/CAS editing. BMC Bioinformatics. 2016 Jul 1 ;17(1):261

- Tanaka A, De Martino A, Amato A, Montsant A, Mathieu B, Rostaing P, Tirichine L, Bowler C. Ultrastructure and Membrane Traffic During Cell Division in the Marine Pennate Diatom Phaeodactylum tricornutum. Protist. 2015 Nov ;166(5):506-21.

- Achal Rastogi, Xin Lin, Bérangère Lombard, Damarys Loew and Leïla Tirichine : Probing the evolutionary history of epigenetic mechanisms : What can we learn from marine diatoms. AIMS Genetics, August 2015, DOI : 10.3934/genet.2015.3.173

- Bailleul B, Berne N, Murik O, Petroutsos D, Prihoda J, Tanaka A, Villanova V, Bligny R, Flori S, Falconet D, Krieger-Liszkay A, Santabarbara S, Rappaport F, Joliot P, Tirichine L, Falkowski PG, Cardol P, Bowler C, Finazzi G. Energetic coupling between plastids and mitochondria drives CO2 assimilation in diatoms. Nature. 2015 Aug 20 ;524(7565):366-9

- Veluchamy A, Rastogi A, Lin X, Lombard B, Murik O, Thomas Y, Dingli F, Rivarola M, Ott S, Liu X, Sun Y, Rabinowicz PD, McCarthy J, Allen AE, Loew D, Bowler C, Tirichine L. An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum. Genome Biol. 2015 May 20 ;16:102

- Morrissey J, Sutak R, Paz-Yepes J, Tanaka A, Moustafa A, Veluchamy A, Thomas Y, Botebol H, Bouget FY, McQuaid JB, Tirichine L, Allen AE, Lesuisse E, Bowler C. A novel protein, ubiquitous in marine phytoplankton, concentrates iron at the cell surface and facilitates uptake. Curr Biol. 2015 Feb 2 ;25(3):364-71

- Abida H, Dolch LJ, Meï C, Villanova V, Conte M, Block MA, Finazzi G, Bastien O, Tirichine L, Bowler C, Rébeillé F, Petroutsos D, Jouhet J, Maréchal E. Membrane glycerolipid remodeling triggered by nitrogen and phosphorus starvation in Phaeodactylum tricornutum. Plant Physiol. 2015 Jan ;167(1):118-36

- Leïla Tirichine, Xin Lin, Yann Thomas, Bérangère Lombard, Damarys Loew and Chris Bowler : Histone extraction protocol from the two model diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana. Marine Genomics. 2014 Feb ;13:21-5.

- Veluchamy A, Lin X, Maumus F, Rivarola M, Bhavsar J, Creasy T, O’Brien K, Sengamalay NA, Tallon LJ, Smith AD, Rayko E, Ahmed I, Crom SL, Farrant GK, Sgro JY, Olson SA, Bondurant SS, Allen A, Rabinowicz PD, Sussman MR, Bowler C, Tirichine L* : Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum. Nat Commun. 2013 Jul 2 ;4:2091.

- Lin X, Tirichine L, Bowler C : Protocol : Chromatin immunoprecipitation (ChIP) methodology to investigate histone modifications in two model diatom species. Plant Methods. 2012 Dec 7 ;8(1):48

- Tirichine L, Bowler C Decoding algal genomes : tracing back the history of photosynthetic life on Earth. Plant J. 2011 Apr ; 66(1):45-57.

- Karsenti E. and the Tara Oceans Consortium (Tirichine L member of the consortium) : A Holistic Approach to Marine Eco-Systems Biology. PLoS Biol. 2011 Oct ;9(10):e1001177.

- P. Andrey¥, K. Kieu¥, G. Lehmann¥, C. Kress¥, L. Tirichine¥, et al : Statistical analysis of 3D images detects regular spatial distributions of centromeres and chromocenters in animal and plant nuclei. PLoS Comput Biol. 2010 Jul 8 ; 6(7). ¥ Equal contribution

- Tirichine L et al. : 3D-Fluorescent In Situ Hybridization protocol using direct labeling on Arabidopsis leaf cryosections or isolated nuclei. Plant Methods 2009 Aug 3 ;5:11

- Tirichine L, Sandal N, Madsen LH, Radutoiu S, Albrektsen AS, Sato S, Asamizu E, Tabata S, Stougaard J. A Gain-of-Function Mutation in a Cytokinin Receptor Triggers Spontaneous Root Nodule Organogenesis. Science (2007) 315, p104.

- Tirichine L et al Deregulation of a Ca2+/calmodulin-dependent kinase leads to spontaneous nodule development. Nature 2006 June 29 ;441(7097):1153-6.

- Tirichine L, Niels Sandal, Euan K. James and Jens Stougaard : Spontaneous root nodule formation in the model legume Lotus japonicus : A novel class of mutants nodulates in absence of Rhizobium. Mol Plant Microbe Interact. 2006 Apr ;19(4):373-82.

- Madsen LH, Tirichine L et al The molecular network governing nodule organogenesis and infection in the model legume Lotus japonicus. Nature Commun. 2010 Apr 12 ;1:10

- Heckmann AB, Sandal N, Bek AS, Madsen LH, Jurkiewicz A, Nielsen MW, Tirichine L, Stougaard J (2011) : Cytokinin induction of root nodule primordia in Lotus japonicus is regulated by a mechanism operating in the root cortex. MPMI, 2011 Nov ;24(11):1385-95

- Rakocevic A, Mondy S, Tirichine L et al., MERE1, a low copy number copia-type retroelement in Medicago truncatula is active during tissue culture. Plant Physiol. 2009 Nov ;151(3):1250-63

- Tirichine L, de Billy F, Huguet T : Mtsym6, a gene conditioning Sinorhizobium strain-specific nitrogen fixation in Medicago truncatula. Plant Physiol. 2000 Jul ;123(3):845-51