Institut de Biologie de l'École Normale Supérieure ENS . CNRS UMR8197 . Inserm U1024 Directeur : Pierre Paoletti

Projet de recherche

I have integrated Olivier Hyrien’s team to study genome replication in eukaryotes. I’m passionate about all aspects of genomics and specialized in bioinformatic method development. I obtained my PhD in 2016 working on the data analysis of next generation sequencing of pharmacogenes. Next, I joined Gang Fang’s team in Icahn School of Medicine at Mount Sinai to work on method implementation for third generation sequencing platforms (Nanopore and PacBio), in particular on the detection of DNA modification in isolated prokaryotes and microbiomes.nalysis and modeling to decipher the dynamics of replication in eukaryotes.

Parcours

Since 2022 : Postdoctoral researcher in Olivier Hyrien team
2016 – 2021 : Postdoctoral in Gang Fang team, Icahn School of Medicine at Mount Sinai, New York, USA
2013 – 2016 : PhD in pharmacogenomic with Chantal Guillemette team, CHU de Québec Research Center, Québec, Canada
2010 – 2012 : M.S. in Bioinformatics, Université de Nantes, France
2009 – 2010 : B.S. in Biology - Biochemistry, Molecular Biology major, Université de Nantes, France
2007 – 2009 : A.S. in Biological Engineering, Biological and Biochemical Analyzes major Université de La Rochelle, France

Publications

Discovering multiple types of DNA methylation from bacteria and microbiome using nanopore sequencing - Nature Methods
https://doi.org/10.1038/s41592-021-01109-3
Tourancheau, A., Mead, E.A., Zhang, XS. and Fang G.

Quantitative profiling of the UGT transcriptome in human drug-metabolizing tissues - The Pharmacogenomics Journal
https://doi.org/10.1038/tpj.2017.5
Tourancheau, A., Rouleau, M., Guauque-Olarte, S., Villeneuve, L., Gilbert, I., Droit, A. and Guillemette, C.

Unravelling the transcriptomic landscape of the major phase II UDP-glucuronosyltransferase drug metabolizing pathway using targeted RNA sequencing - The Pharmacogenomics Journal
https://doi.org/10.1038/tpj.2015.20
Tourancheau, A., Margaillan, G., Rouleau, M., Gilbert, I., Villeneuve, L., Levesque, E., Droit, A. and Guillemette, C.

Divergent expression and metabolic functions of human glucuronosyltransferases through alternative splicing - Cell Report
https://doi.org/10.1016/j.celrep.2016.08.077
Rouleau, M., Tourancheau, A., Girard-Bock, C., Villeneuve, L., Vaucher, J., Duperré, AM., Audet-Delage, Y., Gilbert, I., Popa, I., Droit, A., and Guillemette, C.

Cyclosporine and methotrexate-related pharmacogenomic predictors of acute graft-versus-host disease - Haematologica
https://doi.org/10.3324/haematol.2014.109884
Laverdiere, I., Guillemette, C., Tamouza, R., Loiseau, P., Peffault de Latour, R., Robin, M., Couture, F., Filion, A., Lalancette, M., Tourancheau, A., Charron, D., Socié, G., and Lévesque, E.

A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients - The Pharmacogenomics Journal
https://doi.org/10.1038/tpj.2015.12
Chen, S., Laverdiere, I., Tourancheau, A., Jonker, D., Couture, F., Cecchin, E., Villeneuve, L., Harvey, M., Court, M.H., Innocenti, F., Toffoli, G., Lévesque, E., and Guillemette, C.