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Publications

Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.
Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, Oliet SHR, Groc L.
Elife. 2017 Jun 9 ;6. pii : e25492. doi : 10.7554/eLife.25492.

Optocontrol of glutamate receptor activity by single side-chain photoisomerization.
Klippenstein V, Hoppmann C, Ye S, Wang L, Paoletti P.
Elife. 2017 May 23 ;6. pii : e25808. doi : 10.7554/eLife.25808.

Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations.
Serraz B, Grand T, Paoletti P.
Neuropharmacology. 2016 Oct ;109:196-204.
doi : 10.1016/j.neuropharm.2016.06.008. Epub 2016 Jun 7.

A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
Stroebel D#, Buhl DL#, Knafels JD, Chanda PK, Green M, Sciabola S, Mony L, Paoletti P*, Pandit J*.
Mol Pharmacol. 2016 May ;89(5):541-51. doi : 10.1124/mol.115.103036. Epub 2016 Feb 24.
# Co-first author.
* Co-last author.

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE.
Neuron. 2016 Mar 2 ;89(5):983-99. doi : 10.1016/j.neuron.2016.01.016. Epub 2016 Feb 11.

Presynaptic NMDA receptors : Roles and rules.
Bouvier G, Bidoret C, Casado M, Paoletti P.
Neuroscience. 2015 Dec 17 ;311:322-40. doi : 10.1016/j.neuroscience.2015.10.033. Epub 2015 Oct 24. Review.

Editorial overview : neurosciences : targeting glutamatergic signaling in CNS diseases : new hopes ?
Paoletti P, Pin JP.
Curr Opin Pharmacol. 2015 Feb ;20:iv-vi. doi : 10.1016/j.coph.2015.01.001. Epub 2015 Jan 15.

Controlling NMDA receptor subunit composition using ectopic retention signals.
Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P.
J Neurosci. 2014 Dec 10 ;34(50):16630-6. doi : 10.1523/JNEUROSCI.2736-14.2014.

Allosteric modulators of NMDA receptors : multiple sites and mechanisms.
Zhu S, Paoletti P.
Curr Opin Pharmacol. 2014 Nov 12 ;20C:14-23. doi : 10.1016/j.coph.2014.10.009. Review.

Neuroscience : A structure to remember.
Stroebel D, Paoletti P.
Nature. 2014 Jul 10 ;511(7508):162-3. doi : 10.1038/511162a.

Zinc dynamics and action at excitatory synapses.
Vergnano AM#, Rebola N#, Savtchenko LP#, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C*, Paoletti P*.
Neuron. 2014 Jun 4 ;82(5):1101-14. doi : 10.1016/j.neuron.2014.04.034.
# Co-first author.
* Co-last author.

Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces.
Zhu S#, Riou M#, Yao CA, Carvalho S, Rodriguez PC, Bensaude O, Paoletti P*, Ye S*.
PNAS (USA). 2014 Apr 22 ;111(16):6081-6.
doi : 10.1073/pnas.1318808111. Epub 2014 Apr 8.
# Co-first author.
* Co-last author.

NMDA receptor subunit diversity : impact on receptor properties, synaptic plasticity and disease.
Paoletti P, Bellone C, Zhou Q.
Nat Rev Neurosci. 2013 Jun ;14(6):383-400. doi : 10.1038/nrn3504. Review.
PMID : 23686171 [PubMed - indexed for MEDLINE]

Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.
Zhu S, Stroebel D, Yao CA, Taly A, Paoletti P.
Nat Struct Mol Biol. 2013 Apr ;20(4):477-85. doi : 10.1038/nsmb.2522. Epub 2013 Mar 3.

Expanding the genetic code in Xenopus laevis oocytes.
Ye S, Riou M, Carvalho S, Paoletti P.
Chembiochem. 2013 Jan 21 ;14(2):230-5.

Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging.
Suzuki Y, Goetze TA, Stroebel D, Balasuriya D, Yoshimura SH, Henderson RM, Paoletti P, Takeyasu K, Edwardson JM.
J Biol Chem. 2013 Jan 11 ;288(2):778-84.

Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.
Boulin T, Rapti G, Briseño-Roa L, Stigloher C, Richmond JE, Paoletti P, Bessereau JL.
Nat Neurosci. 2012 Oct ;15(10):1374-81. doi : 10.1038/nn.3197. Epub 2012 Aug 26.

An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.
Riou M, Stroebel D, Edwardson JM, Paoletti P.
PLoS One. 2012 ;7(4):e35134. doi : 10.1371/journal.pone.0035134. Epub 2012 Apr 6.

Synaptic neurotransmitter-gated receptors.
Smart TG, Paoletti P.
Cold Spring Harb Perspect Biol. 2012 Mar 1 ;4(3

Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates.
Marchand P, Becerril-Ortega J, Mony L, Bouteiller C, Paoletti P, Nicole O, Barré L, Buisson A, Perrio C.
Bioconjug Chem. 2012 Jan 18 ;23(1):21-6.

The neurophysiology and pathology of brain zinc.
Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M.
J Neurosci. 2011 Nov 9 ;31(45):16076-85.

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.
Nozaki C#, Vergnano AM#, Filliol D, Ouagazzal AM, Le Goff A, Carvalho S, Reiss D, Gaveriaux-Ruff C, Neyton J, Paoletti P*, Kieffer BL*.
Nat Neurosci. 2011 Jul 3 ;14(8):1017-22.
# Co-first author.
* Co-last author.

Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines.
Mony L, Zhu S, Carvalho S, Paoletti P.
EMBO J. 2011 Jun 17 ;30(15):3134-46.

Molecular basis of NMDA receptor functional diversity.
Paoletti P.
Eur J Neurosci. 2011 Apr ;33(8):1351-65. Review.

Biological roles of trace elements in the brain with special focus on Zn and Fe.
Bohic S, Ghersi-Egea JF, Gibon J, Paoletti P, Arnaud J, Hunot S, Boom A, Bouron A.
Rev Neurol (Paris). 2011 Apr ;167(4):269-79. Review.

Functional evidence for a twisted conformation of the NMDA receptor GluN2A subunit N-terminal domain.
Stroebel D, Carvalho S, Paoletti P.
Neuropharmacology. 2011 Jan ;60(1):151-8

Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
Mony L, Triballeau N, Paoletti P, Acher FC, Bertrand HO.
Bioorg Med Chem Lett. 2010 Sep 15 ;20(18):5552-8.

Fonctionnement des récepteurs-canaux du glutamate : des protéines responsables de la transmission synaptique excitatrice.
Gielen M. 
Médecine Sciences, vol. 26, 65-72. Revue.

Zinc in the physiology and pathology of the CNS.
Sensi SL, Paoletti P, Bush AI, Sekler I.
Nat Rev Neurosci. 2009 Nov ;10(11):780-91. Review.

Allosteric modulators of NR2B-containing NMDA receptors : molecular mechanisms and therapeutic potential.
Mony L, Kew JN, Gunthorpe MJ, Paoletti P.
Br J Pharmacol. 2009 Aug ;157(8):1301-17. Review.

Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Gielen M, Siegler Retchless B, Mony L, Johnson JW, Paoletti P.
Nature. 2009 Jun 4 ;459(7247):703-7.

Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor.
Boulin T#, Gielen M#, Richmond JE, Williams DC, Paoletti P*, Bessereau JL*.
PNAS (USA). 2008 Nov 25 ;105(47):18590-5.
# Co-first author.
* Co-last author.

Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.
Mony L, Krzaczkowski L, Leonetti M, Le Goff A, Alarcon K, Neyton J, Bertrand HO, Acher F, Paoletti P.
Mol Pharmacol. 2009 Jan ;75(1):60-74

Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors.
Alarcon K, Martz A, Mony L, Neyton J, Paoletti P, Goeldner M, Foucaud B.
Bioorg Med Chem Lett. 2008 May 1 ;18(9):2765-70.

Zinc at glutamatergic synapses.
Paoletti P, Vergnano AM, Barbour B, Casado M.
Neuroscience. 2009 Jan 12 ;158(1):126-36.

Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition.
Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J, Paoletti P.
Neuron. 2008 Jan 10 ;57(1):80-93.

A startling role for synaptic zinc.
Kay AR, Neyton J, Paoletti P.
Neuron. 2006 Nov 22 ;52(4):572-4. Review.

NMDA receptor subunits : function and pharmacology.
Paoletti P, Neyton J.
Curr Opin Pharmacol. 2007 Feb ;7(1):39-47. Review.

Relating NMDA receptor function to receptor subunit composition : limitations of the pharmacological approach.
Neyton J, Paoletti P.
J Neurosci. 2006 Feb 1 ;26(5):1331-3.

Modulation of triheteromeric NMDA receptors by N-terminal domain ligands.
Hatton CJ, Paoletti P.
Neuron. 2005 Apr 21 ;46(2):261-74.

The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.
Rachline J, Perin-Dureau F, Le Goff A, Neyton J, Paoletti P.
J Neurosci. 2005 Jan 12 ;25(2):308-17.

Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.
Malherbe P, Mutel V, Broger C, Perin-Dureau F, Kemp JA, Neyton J, Paoletti P, Kew JN.
J Pharmacol Exp Ther. 2003 Dec ;307(3):897-905. Epub 2003 Oct 8.

Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.
Perin-Dureau F, Rachline J, Neyton J, Paoletti P.
J Neurosci. 2002 Jul 15 ;22(14):5955-65.

High-affinity Zn block in recombinant N-methyl-D-aspartate receptors with cysteine substitutions at the Q/R/N site.
Amar M, Perin-Dureau F, Neyton J.
Biophys J. 2001 Jul ;81(1):107-16.

Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.
Paoletti P, Perin-Dureau F, Fayyazuddin A, Le Goff A, Callebaut I, Neyton J.
Neuron. 2000 Dec ;28(3):911-25.

Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.
Fayyazuddin A1, Villarroel A, Le Goff A, Lerma J, Neyton J.
Neuron. 2000 Mar ;25(3):683-94.