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Auguste Genovesio

Computational Bioimaging
and Bioinformatics

This team is part of the Computational Biology Center.

The research project of our team is the study of cellular morphology and dynamics at large scale. We are interested in characterizing the morphological heterogeneity of cellular responses to perturbations. We thus work to identify mechanical or molecular factors of cell morphology, organization and activity in different contexts. In this perspective, on one hand we contribute to generate large data sets of images or gene expression. On the other hand, we interpret these large data sets to produce and validate predictive models. As the scale of the data produced this way constrains us to full automation and quantitative approaches, we develop algorithms and tools for the analysis of large image data. The members of our team bring together a wide range of expertise such as machine and deep learning, computer science, applied mathematics, biophysics and genomic analysis. We apply our approaches to scientific questions we raise such as understanding the action of small compounds with the support of our collaborators from the Curie Institute next door and the pharmaceutical industry. We also develop approaches dedicated to fundamental biology research through a strong interaction with our colleagues at IBENS, Collège de France and ESPCI in various subfields such as functional genomics, developmental biology and neuroscience.

Recent selected publications

(Full list of publications and patents available here )

Unraveling spatial cellular pattern by computational tissue shuffling
E. Laruelle, N. Spassky, A. Genovesio
2020, Communications Biology

In vivo large-scale analysis of Drosophila neuronal calcium traces by automated tracking of single somata
F Delestro*, L Scheunemann*, M Pedrezzani, P Tchenio, T Preat, A Genovesio
2020, Scientific Reports

Artificially decreasing cortical tension generates aneuploidy in mouse oocytes
I Bennabi, F Crozet, E Nikalayevich, A Chaigne, G Letort, M Manil-Ségalen, C Campillo, C Cadart, A Othmani, R Attia, A Genovesio, M-H Verlhac, M-E Terret
2020, Nature communications

Active Fluctuations of the Nuclear Envelope Shape the Transcriptional Dynamics in Oocytes
M Almonacid, A Al Jord, S El-Hayek, A Othmani, F Coulpier, S Lemoine, K Miyamoto, R Grosse, C Klein, T Piolot, P Mailly, R Voituriez, A Genovesio, M-H Verlhac
2019, Developmental Cell

PySpacell: A Python Package for Spatial Analysis of Cell Images.
F Rose, L Rappez, SH Triana, T Alexandrov, A Genovesio
2019, Cytometry Part A

Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
Ortiz-Álvarez G*, Daclin M*, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, Clavreul S, Lalioti ME, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio A, Spassky N
2019 Neuron

ALFA: annotation landscape for aligned reads
M Bahin*, B F Noel*, V Murigneux, C Bernard, L Bastianelli, H Le Hir, A Lebreton, A Genovesio
2019, BMC Genomics

Monitored eCLIP: high accuracy mapping of RNA-protein interactions
R Hocq*, J Paternina*, Q Alasseur, A Genovesio, H Le Hir
2018, Nucleic Acid Research

Ependymal cilia beating induces an actin network to protect centrioles against shear stress
A Mahuzier, A Shihavuddin, C Fournier, P Lansade, M Faucourt, N Menezes, A Meunier, M Garfa-Traoré, M-F Carlier, R Voituriez, A Genovesio, N Spassky, N Delgehyr
2018, Nature Communications

High‐Throughput Optical Mapping of Replicating DNA
F De Carli*, N Menezes*, W Berrabah, V Barbe, A Genovesio, O Hyrien
2018, Small Methods

Smooth 2D manifold extraction from 3D image stack
A Shihavuddin*, S Basu*, E Rexhepaj, F Delestro, N Menezes, SM Sigoillot, E Del Nery, F Selimi, N Spassky, A Genovesio
2017, Nature Communications

Compound Functional Prediction Using Multiple Unrelated Morphological Profiling Assays
F Rose*, S Basu*, E Rexhepaj, A Chauchereau, E Del Nery, A Genovesio
2017, SLAS Technology

Calibrated mitotic oscillator drives motile ciliogenesis
A Al Jord, A Shihavuddin, R Servignat d’Aout, M Faucourt, A Genovesio, A Karaiskou, J Sobczak-Thépot, N Spassky, A Meunier
2017, Science

Detection and tracking of overlapping cell nuclei for large scale mitosis analyses
Y Li*, F Rose*, F di Pietro, X Morin, A Genovesio
2016, BMC bioinformatics