Staff scientist (CR1 CNRS)
1991. Degree in Biology from University of Lisbon, Portugal
1995. Ph.D. in Molecular Biology with first class honors from University of Lisbon, Portugal
1995-2000. Post-doctoral fellow at the Institut Jacques Monod (Danièle Touati’s lab, Paris): study of the role of the bacterial superoxide dismutase during the symbiosis of Sinorhizobium meliloti and the leguminous plant alfalfa.
200-2002. Post-doctoral fellow at the Institut Jacques Monod (Jean-Michel Camadro’s lab, Paris): study of iron homeostasis and oxidative stress in the yeast S. cerevisiae.
2002. Recruited as Investigator (Chargé de Recherche) at the CNRS in France.
2002-2011. Work in the same lab (IJM) on the effect of frataxin-deficiency (that cause a neurodegenerative disease in humans) on oxidative stress response and cell death in yeast and mammalian cells.
2012-. Move to Patrick Charnay’s lab at the ISBN to study adult neuronal stem cells in mice.
Cellular oxidative stress response
S. Lefevre, C. Brossas, F. Auchère, N. Boggetto, J.M. Camadro and R. Santos (2012) Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells. Hum. Mol. Genet. 21, 4060-4072.
S. Lefevre, D. Sliwa, P. Rustin, J.M. Camadro and R. Santos (2012) Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells. Biochem. Biophys. Res. Comms. 418, 336-341.
D. Sliwa, J. Dairou, J.M. Camadro and R. Santos (2012) Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells. Biochem. J. 441, 945-953.
S. Lefevre, D. Sliwa, F. Auchère, C. Brossas, C. Ruckenstuhl, N. Boggetto, E. Lesuisse, F. Madeo, J.M. Camadro and R. Santos (2012) The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells. FEBS Lett. 586, 143-148.
Bayot, R. Santos, J.M. Camadro and P. Rustin (2011) Friedreich ataxia: the vicious circle hypothesis revisited. BMC Med. 9, 112.
Seguin, R. Santos, D. Pain, A. Dancis, J.M. Camadro and E. Lesuisse (2011) Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1). J. Biol. Chem. 286, 6071-6079.
R. Santos, S. Lefevre, D. Sliwa, A. Seguin, J.M. Camadro and E. Lesuisse (2010) Friedreich’s ataxia: molecular mechanisms, redox considerations and therapeutic opportunities. Antioxid. Redox Signal. 13, 651-690.
Seguin, R. Sutak, A.L. Bulteau, R. Garcia-Serres, J.L. Oddou, S. Lefevre, R. Santos, A. Dancis, J.M. Camadro, J.M. Latour and E. Lesuisse (2010) Evidences that yeast frataxin is not an iron storage protein in vivo. Biochim. Biophys. Acta - Mol. Basis Dis. 1802, 531-538.